Prediction of Diabetic Nephropathy Using Urine Proteomic Profiling 10 Years Prior to Development of Nephropathy

OBJECTIVE:--We examined whether proteomic technologies identify novel urine proteins associated with subsequent development of diabetic nephropathy in subjects with type 2 diabetes before evidence of microalbuminuria. RESEACH DESIGN AND METHODS--In a nested case-control study of Pima Indians with ty...

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Veröffentlicht in:	Diabetes care 2007-03, Vol.30 (3), p.638-643
Hauptverfasser:	Otu, Hasan H, Can, Handan, Spentzos, Dimitrios, Nelson, Robert G, Hanson, Robert L, Looker, Helen C, Knowler, William C, Monroy, Manuel, Libermann, Towia A, Karumanchi, S. Ananth, Thadhani, Ravi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Albuminuria Biological and medical sciences Blood Pressure Creatinine - blood Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - urine Diabetes. Impaired glucose tolerance Diabetic nephropathies Diabetic Nephropathies - epidemiology Diabetic Nephropathies - genetics Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gene Expression Profiling Glycated Hemoglobin A - analysis Health aspects Humans India - epidemiology Kidneys Male Mass Spectrometry Medical sciences Middle Aged Nephrology. Urinary tract diseases Predictive Value of Tests Proteins Proteinuria Proteomics Reference Values Reproducibility of Results Risk factors Time Factors Transplants & implants Urinary system involvement in other diseases. Miscellaneous
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Zusammenfassung:	OBJECTIVE:--We examined whether proteomic technologies identify novel urine proteins associated with subsequent development of diabetic nephropathy in subjects with type 2 diabetes before evidence of microalbuminuria. RESEACH DESIGN AND METHODS--In a nested case-control study of Pima Indians with type 2 diabetes, baseline (serum creatinine
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc06-1656