Maternal Insulin Therapy Increases Fetal Endothelial Progenitor Cells During Diabetic Pregnancy

The following data about the mother were recorded: age, pregravidic BMI, weight increase, smoking habit, family history of cardiovascular disease, arterial blood pressure, and type of antidiabetic treatment. The association between maternal insulin therapy and higher fetal CD34^sup +^KDR^sup +^ cell...

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Veröffentlicht in:	Diabetes care 2008-04, Vol.31 (4), p.808-810
Hauptverfasser:	Fadini, Gian Paolo, Baesso, Ilenia, Agostini, Carlo, Cuccato, Emily, Nardelli, Giovanni Battista, Lapolla, Annunziata, Avogaro, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Biological and medical sciences Birth weight Birth Weight - drug effects Bone marrow Cardiovascular disease Complications and side effects Development and progression Diabetes Diabetes in pregnancy Diabetes therapy Diabetes, Gestational - drug therapy Diabetes. Impaired glucose tolerance Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - drug effects Endothelium, Vascular - embryology Endothelium, Vascular - physiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fetal Blood - cytology Fetal Blood - drug effects Fetus - drug effects Fetus - physiology Glycated Hemoglobin A - metabolism Health aspects Humans Hyperglycemia Hyperglycemia - prevention & control Hypoglycemic Agents - therapeutic use Infant, Newborn Insulin Insulin - therapeutic use Medical sciences Metabolic diseases Miscellaneous Physiological aspects Pregnancy Pregnancy in Diabetics - drug therapy Pregnant women Public health. Hygiene Public health. Hygiene-occupational medicine Stem Cells - cytology Stem Cells - drug effects Womens health
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Zusammenfassung:	The following data about the mother were recorded: age, pregravidic BMI, weight increase, smoking habit, family history of cardiovascular disease, arterial blood pressure, and type of antidiabetic treatment. The association between maternal insulin therapy and higher fetal CD34^sup +^KDR^sup +^ cell count remained significant after correction for maternal age, hypertension, plasma glucose, family history for cardiovascular disease, cholesterol and triglyceride values, and pregravidic BMI.
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc07-1996