Biomimetic synthesis via polyepoxide cyclizations

Biomimetic synthesis via polyepoxide cyclizations

The biomimetic synthesis of -fused polycyclic ether natural products involving a cascade of stereospecific and regioselective oxacyclizations of polyepoxide substrates is described as applied to the synthesis of polyoxepane and polypyran structures. In addition, an extension of biomimetic polyene cy...

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Veröffentlicht in:Pure and applied chemistry 2007-02, Vol.79 (2), p.281-291
Hauptverfasser: McDonald, Frank E., Tong, Rongbiao, Valentine, Jason C., Bravo, Fernando
Format: Artikel
Sprache:eng
Schlagworte:
biomimetic synthesis
Biomimetics
Natural products
polycyclic ethers
polycyclic terpenes
polyepoxides
Substrates
Synthesis
tandem cyclizations
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Zusammenfassung:The biomimetic synthesis of -fused polycyclic ether natural products involving a cascade of stereospecific and regioselective oxacyclizations of polyepoxide substrates is described as applied to the synthesis of polyoxepane and polypyran structures. In addition, an extension of biomimetic polyene cyclizations to terpenoid natural products is outlined.
ISSN:0033-4545
1365-3075
DOI:10.1351/pac200779020281