Effects of asiatic acid, an active constituent in Centella asiatica (L.): restorative perspectives of streptozotocin-nicotinamide induced changes on lipid profile and lipid metabolic enzymes in diabetic rats

The present study was aimed to evaluate the restorative efficacy of asiatic acid (AA), an active constituent in Centella asiatica (L.) in streptozotocin (STZ)-nicotinamide (NAD)-induced diabetic rats. Male Wistar albino rats were made diabetic with STZ-NAD administration and assessed the effect of A...

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Veröffentlicht in:	Comparative clinical pathology 2019-10, Vol.28 (5), p.1321-1329
Hauptverfasser:	Swapna, K., Sathibabu Uddandrao, V. V., Parim, Brahmanaidu, Ravindarnaik, R., Suresh, P., Ponnusamy, Ponmurugan, Balakrishnan, Santhanaraj, Vadivukkarasi, S., Harishankar, N., Reddy, K. Prathap, Nivedha, P. R., Saravanan, Ganapathy
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidiabetics Body weight Centella asiatica Cholesterol Coenzyme A Diabetes Diabetes mellitus Fatty acids Fatty liver Hematology Hyperlipidemia Insulin Insulin resistance Kidneys Lecithin Lipase Lipids Lipoprotein lipase Lipoproteins Liver Medicine Medicine & Public Health Metabolism NAD Nicotinamide Oncology Original Article Pathology Phospholipids Reductase Rodents Steatosis Streptozocin Supplements Triglycerides
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Zusammenfassung:	The present study was aimed to evaluate the restorative efficacy of asiatic acid (AA), an active constituent in Centella asiatica (L.) in streptozotocin (STZ)-nicotinamide (NAD)-induced diabetic rats. Male Wistar albino rats were made diabetic with STZ-NAD administration and assessed the effect of AA (20, 30, and 40 mg/kg body weight per day, for 45 days) on body weight, glucose, insulin, insulin resistance, lipid metabolic parameters in plasma and tissue (liver and kidney), and histopathology of liver in control and experimental diabetic rats. A significant ( p
ISSN:	1618-5641 1618-565X
DOI:	10.1007/s00580-019-02955-6