Effect of Cisapride on Acid Gastro-Oesophageal Reflux during Treatment with Caffeine

About 50% of preterm infants and neonates receiving methylxanthines for respiratory stimulation will develop a pathological gastro-oesophageal reflux (GOR) pattern. In the face of potential GOR-related complications the effect of a concomitant treatment with a prokinetic agent, such as cisapride, sh...

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Veröffentlicht in:	Biology of the neonate 2000-02, Vol.77 (2), p.92-95
Hauptverfasser:	Kentrup, H., Baisch, H.-J., Kusenbach, G., Heimann, G., Skopnik, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Caffeine - blood Caffeine - therapeutic use Cisapride - administration & dosage Cisapride - adverse effects Cisapride - therapeutic use Drug toxicity and drugs side effects treatment Gastroesophageal Reflux - drug therapy Gastrointestinal Agents - administration & dosage Gastrointestinal Agents - therapeutic use Humans Hydrogen-Ion Concentration Infant, Newborn Infant, Premature, Diseases - drug therapy Medical sciences Original Paper Pharmacology. Drug treatments Toxicity: digestive system
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Zusammenfassung:	About 50% of preterm infants and neonates receiving methylxanthines for respiratory stimulation will develop a pathological gastro-oesophageal reflux (GOR) pattern. In the face of potential GOR-related complications the effect of a concomitant treatment with a prokinetic agent, such as cisapride, should be evaluated. In this study 32 formerly preterm infants were studied simultaneously by 24-hour oesophageal pH monitoring and cardio-respirogram before the presumed end of caffeine treatment. In 14 of these infants a reflux index (RI; percentage of recording time) of more than 4% could be detected (pH
ISSN:	1661-7800 0006-3126 1661-7819 1421-9727
DOI:	10.1159/000014200