Subclinical activation of lupus nephritis by recombinant human growth hormone

The effect of growth hormone (GH) on subclinical disease activity in a 15-year-old boy with previously quiescent lupus nephritis and chronic renal failure is described. Institution of supraphysiological doses of GH resulted in a rise in erythrocyte sedimentation rate, decrease in serum complement, r...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 1998-02, Vol.12 (2), p.133-135
Hauptverfasser:	YAP, H.-K, LOKE, K.-Y, MURUGASU, B, LEE, B.-W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Sedimentation Child Complement System Proteins - metabolism DNA - immunology DNA - metabolism Glomerulonephritis Growth Disorders - drug therapy Growth Disorders - etiology Growth Hormone - adverse effects Growth Hormone - therapeutic use Humans Kidney Failure, Chronic - complications Lupus Nephritis - chemically induced Lupus Nephritis - physiopathology Lymphocyte Count Lymphocyte Subsets - drug effects Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Zusammenfassung:	The effect of growth hormone (GH) on subclinical disease activity in a 15-year-old boy with previously quiescent lupus nephritis and chronic renal failure is described. Institution of supraphysiological doses of GH resulted in a rise in erythrocyte sedimentation rate, decrease in serum complement, rise in anti-DNA antibody titers, and increase in T-cell activation markers, all of which improved following cessation of GH treatment.
ISSN:	0931-041X 1432-198X
DOI:	10.1007/s004670050421