The role of early renal biopsy in cyclosporin induced thrombotic microangiopathy

Thrombotic microangiopathy is an uncommon complication of cyclosporin immunosuppression following renal transplantation. We present a 15-year-old girl who developed clinical features of acute rejection, but in whom an early biopsy revealed thrombotic microangiopathy, allowing a change to FK506 immun...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 1999-09, Vol.13 (7), p.564-566
Hauptverfasser:	BURKE, G. A. A, MCGRAW, M. E, MACIVER, A. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Biopsy Capillaries - pathology Cyclosporine - adverse effects Female Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Investigative techniques, diagnostic techniques (general aspects) Kidney - pathology Kidney Glomerulus - blood supply Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Retreatment Tacrolimus - therapeutic use Thrombosis - chemically induced Thrombosis - pathology Urinary system
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Zusammenfassung:	Thrombotic microangiopathy is an uncommon complication of cyclosporin immunosuppression following renal transplantation. We present a 15-year-old girl who developed clinical features of acute rejection, but in whom an early biopsy revealed thrombotic microangiopathy, allowing a change to FK506 immunosuppression resulting in excellent graft recovery.
ISSN:	0931-041X 1432-198X
DOI:	10.1007/s004670050743