Effect of Destruction of the Suprachiasmic Hypothalamic Nuclei on Autosensitization in the Organism of Rats

Examination of the effects of destruction of the suprachiasmic hypothalamic nuclei in rats allowed us to study the interaction between the nervous, immune, and endocrine systems, as well the involvement of structures of the anterior hypothalamus in the neuroimmune interaction. After such an intervention, we measured the following immunological indices: the content of leukocytes in the peripheral blood, the level of circulating immune complexes, and the sensitization of immunocompetent cells to organism's own tissues (of a few CNS structures, thymus, spleen, kidneys, and heart). Our experiments prove the existence of significant interaction between the nervous, immune, and endocrine systems and support the concept of a noticeable involvement of the suprachiasmic nuclei in the control of tolerant relations between the immune system and cells of the organism's own tissues.