Liquid transport properties of porcine tracheal epithelium

Department of Physiology, College of Medicine, University of South Alabama, Mobile, Alabama 36688 Because of its possible importance to the etiology of cystic fibrosis lung disease, the ion and water transport properties of tracheal epithelium were studied. Net liquid flux ( J V ) across porcine tra...

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Veröffentlicht in:	Journal of applied physiology (1985) 2001-08, Vol.91 (2), p.797-802
Hauptverfasser:	Crews, Angela, Taylor, Aubrey E, Ballard, Stephen T
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Air breathing Animals Biological and medical sciences Cystic fibrosis Fluids Fundamental and applied biological sciences. Psychology Hogs In Vitro Techniques Ions Membranes Osmolar Concentration Proteins Respiratory Mucosa - drug effects Respiratory Mucosa - physiology Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Sucrose - pharmacology Swine Throat Trachea - physiology Vertebrates: respiratory system
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Beschreibung
Zusammenfassung:	Department of Physiology, College of Medicine, University of South Alabama, Mobile, Alabama 36688 Because of its possible importance to the etiology of cystic fibrosis lung disease, the ion and water transport properties of tracheal epithelium were studied. Net liquid flux ( J V ) across porcine tracheal epithelium was measured in vitro using blue dextran as a volume probe. Luminal instillation of isosmotic sucrose solution (280 mM) induced a small net secretion of liquid (7.0 ± 1.7 nl · cm 2 · s 1 ), whereas luminal hyposmotic sucrose solutions (220 or 100 mM) induced substantial and significant ( P
ISSN:	8750-7587 1522-1601
DOI:	10.1152/jappl.2001.91.2.797