Exosomes: fighting cancer with cancer

Exosomes: fighting cancer with cancer

Exosomes are nanovesicles secreted by many cells, including cancer cells. Extensive research has been carried out to validate potential applications of exosomes and to evaluate their efficiency in a wide range of diseases, including cancer. The current knowledge on the origin, biogenesis and composi...

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Veröffentlicht in:Therapeutic delivery 2019-01, Vol.10 (1), p.37-61
Hauptverfasser: Alyamani, Hanin, Obeid, Mohammad A, Tate, Rothwelle J, Ferro, Valerie A
Format: Artikel
Sprache:eng
Schlagworte:
angiogenesis
Antigens
Antineoplastic Agents - administration & dosage
Biopsy
Biosynthesis
Calcification
Cancer
Dendritic cells
diagnostic
Disease
Disease Progression
Drug Carriers
Drug Compounding
Exosomes
Humans
immune system
immunosuppression
Immunotherapy
Kinases
Melanoma
miRNA
Nanoparticles
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - pathology
nucleic acid
progression
Prostate
Proteins
therapeutic
Tumor Microenvironment
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Beschreibung
Zusammenfassung:Exosomes are nanovesicles secreted by many cells, including cancer cells. Extensive research has been carried out to validate potential applications of exosomes and to evaluate their efficiency in a wide range of diseases, including cancer. The current knowledge on the origin, biogenesis and composition of exosomes is described. This review then focuses on the use of exosomes in cancer diagnostics and therapeutics.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2018-0051