Improving the bioavailability of curcumin: is micro/nanoencapsulation the key?

[...]some articles have reported the action of CUR in Alzheimer's disease by inhibiting and reduction Aβ oligomers and lowering cell cytotoxicity, suppression of inflammation and oxidative damage, as well as, improving cognitive deficits (11). CUR is highly lipophilic, displays log P 3.29, and has demonstrated photosensitivity, low solubility in aqueous solutions and under alkaline conditions (pH >7), which makes them susceptible to degradation because of the formation of phenylate anion, increasing the production of CUR radicals (5,16). [...]the development of micro/nanoparticulate systems could improve the stability to light degradation, for example. [...]liposomes containing CUR have been reported to present low toxicity, biodegradability and biocompatibility (5,19). [...]CUR has been incorporated in other drug-delivery systems, such as lyotropic liquid crystal systems, foams, micelles, hydrogels and nanofibers (19).