Synthesis of New Camphane-Type Amides: Potential Synthetic Adaptogenes

Synthesis of New Camphane-Type Amides: Potential Synthetic Adaptogenes

A significant effect of the steric factor on the activity of 3,5-dimethyl-1 H -pyrazolide as an acylating agent has been found using the example of acylation of camphane-type monoamines. The predominant contribution of the catalytic hydrogenation as a component of the Schwenk-Papa reaction has been...

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Veröffentlicht in:Russian journal of general chemistry 2019-03, Vol.89 (3), p.399-404
Hauptverfasser: Novakov, I. A., Brunilin, R. V., Butov, G. M., Vernigora, A. A., Navrotskii, M. B., Yablokov, A. S., Voloboev, S. N.
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Amides
Amines
Catalysis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hydrogenation
Hypothermia
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Zusammenfassung:A significant effect of the steric factor on the activity of 3,5-dimethyl-1 H -pyrazolide as an acylating agent has been found using the example of acylation of camphane-type monoamines. The predominant contribution of the catalytic hydrogenation as a component of the Schwenk-Papa reaction has been confirmed by the synthesis of 4-chlorobenzoyl derivatives.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219030058