Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361

Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy and radiation therapy in vitro. Because classical PARP-1 inhibitors have limited clinical utility, we investigated whether AG14361, a novel po...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2004-01, Vol.96 (1), p.56-67
Hauptverfasser:	CALABRESE, Christopher R, ALMASSY, Robert, LI, Jianke, MAEGLEY, Karen, NEWELL, David R, NOTARIANNI, Elena, STRATFORD, Ian J, SKALITZKY, Donald, THOMAS, Huw D, WANG, Ian-Zhen, WEBBER, Stephen E, WILLIAMS, Kaye J, BARTON, Stephanie, CURTIN, Nicola J, BATEY, Michael A, CALVERT, A. Hilary, CANAN-KOCH, Stacie, DURKACZ, Barbara W, HOSTOMSKY, Zdenek, KUMPF, Robert A, KYLE, Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Azulenes Benzodiazepines - pharmacology Biological and medical sciences Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - radiotherapy Cell Line, Tumor Chemotherapy Colorectal Neoplasms - drug therapy Colorectal Neoplasms - radiotherapy Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Diseases of the digestive system Drug Resistance, Neoplasm - drug effects Enzyme Inhibitors - pharmacology Gamma Rays - therapeutic use Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects General aspects Humans Lung Neoplasms - drug therapy Lung Neoplasms - radiotherapy Medical research Medical sciences Mice Pharmacology. Drug treatments Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Radiation-Sensitizing Agents - pharmacology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Temozolomide Transplantation, Heterologous
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Zusammenfassung:	Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy and radiation therapy in vitro. Because classical PARP-1 inhibitors have limited clinical utility, we investigated whether AG14361, a novel potent PARP-1 inhibitor (inhibition constant
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/djh005