Synthesis of trisubstituted furans via Ag-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines

Synthesis of trisubstituted furans via Ag-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines

A silver(I)-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines is described to synthesize trisubstituted furans in moderate to good yields. Tertiary amine is also efficient in this reaction. This transformation proceeds smoothly with the formation of C–N or C–C bond...

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Veröffentlicht in:Chemical papers 2018-03, Vol.72 (3), p.691-696
Hauptverfasser: He, Ting, Chi, Yaling, Chen, Yuantao
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Aromatic compounds
Biochemistry
Biotechnology
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Functional groups
Furans
Industrial Chemistry/Chemical Engineering
Materials Science
Medicinal Chemistry
Original Paper
Silver
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Zusammenfassung:A silver(I)-catalyzed cascade heterocyclization of 2-(1-alkynyl)-2-alken-1-ones with aryl-amines is described to synthesize trisubstituted furans in moderate to good yields. Tertiary amine is also efficient in this reaction. This transformation proceeds smoothly with the formation of C–N or C–C bonds in one-pot with good functional group tolerance under mild conditions. Graphical Abstract
ISSN:2585-7290
0366-6352
1336-9075
DOI:10.1007/s11696-017-0323-4