Enantioselective Hydrogenation of Ketones using Different Metal Complexes with a Chiral PNP Pincer Ligand

The synthesis of different metal pincer complexes coordinating to the chiral PNP ligand bis(2‐((2R,5R)‐2,5‐dimethyl‐phospholanoethyl))amine is described in detail. The characterized complexes with Mn, Fe, Re and Ru as metal centers showed good activities regarding the reduction of several prochiral...

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Veröffentlicht in:	Advanced synthesis & catalysis 2019-04, Vol.361 (8), p.1913-1920
Hauptverfasser:	Garbe, Marcel, Wei, Zhihong, Tannert, Bianca, Spannenberg, Anke, Jiao, Haijun, Bachmann, Stephan, Scalone, Michelangelo, Junge, Kathrin, Beller, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Asymmetric Catalysis Asymmetric Hydrogenation Chiral Alcohols Chiral Pincer Coordination compounds Enantiomers Iron Ketones Ligands Manganese Noble metals Prochiral Ketones Selectivity Substrates
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Beschreibung
Zusammenfassung:	The synthesis of different metal pincer complexes coordinating to the chiral PNP ligand bis(2‐((2R,5R)‐2,5‐dimethyl‐phospholanoethyl))amine is described in detail. The characterized complexes with Mn, Fe, Re and Ru as metal centers showed good activities regarding the reduction of several prochiral ketones. Comparing these catalysts, the non‐noble metal complexes produced best selectivities not only for aromatic substrates, but also for different kinds of aliphatic ones leading to enantioselectivities up to 99% ee. Theoretical investigations elucidated the mechanism and rationalized the selectivity.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201801511