Roles of Arrest-Defective Protein 1^sup 225^ and Hypoxia-Inducible Factor 1[alpha] in Tumor Growth and Metastasis

Vascular endothelial growth factor A (VEGFA), a critical mediator of tumor angiogenesis, is a well-characterized target of hypoxia-inducible factor 1 (HIF-1). Murine arrest-defective protein 1A acetylates HIF-1α, triggering its degradation, and thus may play a role in decreased expression of VEGFA. Lee et al examine the role of mARD1A ^sup225^ in the regulation of both primary tumor growth and metastatic disease. They generate mARD1A ^sup225^ -expressing transgenic mice to determine whether mARD1A ^sup225^ plays a physiologically important role in regulating tumor growth via HIF-1α and VEGFA.