A novel disposable sensor based on gold digital versatile disc chip modified with graphene oxide decorated with Ag nanoparticles/β-cyclodextrin for voltammetric measurement of naproxen

Schematic of gold-DVD electrode (G-DVD) construction. Inserted Figure: AFM image of gold film surface. [Display omitted] •A voltammetric sensor based on AgNPs@GO-β-CD/G-DVD electrode was fabricated.•Digital versatile discs can be readily used to give cheap reproducible Au electrodes.•The modified electrode shows remarkable performance for the detection of naproxen.•The proposed method was successfully applied to the analysis of commercial tablets and human urine samples. A novel disposable electrochemical sensor was constructed from a gold digital versatile disc (G-DVD) modified with graphene oxide decorated with Ag nanoparticles and β-cyclodextrin (AgNPs@GO-β-CD) for quantitative measurement of naproxen (NAP) in solutions. The surface morphology and elemental distribution of the electrode surface, were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy. Cyclic voltammetry and differential pulse voltammetry techniques were used to evaluate the analytical performance of the modified gold-DVD electrode to the NAP molecules. The fabricated sensor showed an excellent electrocatalytic activity towards oxidation of NAP molecules. The calibration plot was linear within the concentration range of 0.4 μM to 80 μM of NAP. The limits of detection and quantification were found to be: 0.023 μM (S/N = 3) and 0.08 μM (S/N = 10), respectively. The reproducibility of the electrode was checked and the RSD value was estimated 2.5% and the repeatability of the developed sensor was evaluated and the RSD was obtained 3.2%. The proposed electrochemical sensor, was successfully applied for measurement of NAP in some real samples.