ANTICONVULSANTS AND PARENTAL EPILEPSY IN THE DEVELOPMENT OF BIRTH DEFECTS

ANTICONVULSANTS AND PARENTAL EPILEPSY IN THE DEVELOPMENT OF BIRTH DEFECTS

The results of two studies, one in Finland and one in the U.S.A., raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself. In the U.S.A., drug-exposure information was collected before delive...

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Veröffentlicht in:The Lancet (British edition) 1976-02, Vol.307 (7954), p.272-275
Hauptverfasser: Shapiro, Samuel, Hartz, StuartC, Siskind, Victor, Mitchell, AllenA, Slone, Dennis, Rosenberg, Lynn, Monson, RichardR, Heinonen, OlliP, Idänpàan-Heikkilä, Juhana, Häró, Sakari, Saxén, Lauri
Format: Artikel
Sprache:eng
Schlagworte:
Anticonvulsants
Birth defects
Children
Congenital defects
Drug delivery systems
Epilepsy
Fetuses
Phenytoin
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Beschreibung
Zusammenfassung:The results of two studies, one in Finland and one in the U.S.A., raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself. In the U.S.A., drug-exposure information was collected before delivery in a cohort of 50 282 mother/child pairs. The total malformation-rate in 305 children born to epileptic mothers was 10·5%, as against 6·4% in the remainder (p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(76)91403-3