Is [Beta]-glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?

Is [Beta]-glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?

β-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of β-glucuronidase was surprisingly observed, even within normal range. These findings do not...

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Veröffentlicht in:Human & experimental toxicology 2008-05, Vol.27 (5), p.431
Hauptverfasser: Sabbe, MB, Desruelles, D, Lissens, W
Format: Artikel
Sprache:eng
Schlagworte:
Enzymes
Medical diagnosis
Pesticides
Poisoning
Toxicology
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Zusammenfassung:β-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of β-glucuronidase was surprisingly observed, even within normal range. These findings do not support the hypothesis that β-glucuronidase is a useful biomarker for acute organophosphorus poisoning in humans. [PUBLICATION ABSTRACT]
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327108094614