SUCCESSFUL FETAL LIVER TRANSPLANTATION IN A CHILD WITH SEVERE COMBINED IMMUNODEFICIENCY

SUCCESSFUL FETAL LIVER TRANSPLANTATION IN A CHILD WITH SEVERE COMBINED IMMUNODEFICIENCY

Following transplantation with allogeneic fetal liver, a boy with severe combined immunodeficiency and adenosine-deaminase (A.D.A.) deficiency developed immunocompetent T and B cells in an orderly manner. Engraftment was indicated by appearance of A.D.A. activity and donor-lymphocyte and red-cell an...

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Veröffentlicht in:The Lancet (British edition) 1975-11, Vol.306 (7940), p.850-853
Hauptverfasser: Keightley, RichardG, Lawton, AlexanderR, Cooper, MaxD, Yunis, EdmondJ
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine
Adenosine deaminase
Antigens
Enzymes
Fetuses
Glomerulonephritis
Laboratory animals
Liver
Liver transplantation
Liver transplants
Lymphocytes
Lymphocytes B
Mutagenesis
Mutation
Nephrotic syndrome
Pediatrics
Severe combined immunodeficiency
Transplantation
Transplants & implants
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Beschreibung
Zusammenfassung:Following transplantation with allogeneic fetal liver, a boy with severe combined immunodeficiency and adenosine-deaminase (A.D.A.) deficiency developed immunocompetent T and B cells in an orderly manner. Engraftment was indicated by appearance of A.D.A. activity and donor-lymphocyte and red-cell antigens. The child remained free of major infections until one year later when he developed an ultimately fatal nephrotic syndrome associated with immune-complex glomerulonephritis.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(75)90238-X