Divided Doses for Methadone Maintenance

When methadone maintenance was first developed as a treatment for heroin dependence, the once-daily regimen was instituted as a result of methadone's long half-life and ease of administration in a clinic setting requiring on-site administration (4).

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Bibliographische Detailangaben
Veröffentlicht in:	The American journal of psychiatry 2008-03, Vol.165 (3), p.303-305
1. Verfasser:	Adinoff, Bryon
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - therapeutic use Dose-Response Relationship, Drug Drug Administration Schedule Heroin Heroin Dependence - metabolism Heroin Dependence - prevention & control Heroin Dependence - rehabilitation Humans Medical imaging Methadone Methadone - administration & dosage Methadone - pharmacokinetics Methadone - therapeutic use Patients Substance abuse treatment
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Beschreibung
Zusammenfassung:	When methadone maintenance was first developed as a treatment for heroin dependence, the once-daily regimen was instituted as a result of methadone's long half-life and ease of administration in a clinic setting requiring on-site administration (4).
ISSN:	0002-953X 1535-7228
DOI:	10.1176/appi.ajp.2007.07121944