Annulation of pyrrole ring in 4-acylpyridine-3,5-dicarbonitriles in the presence of ammonia

Annulation of pyrrole ring in 4-acylpyridine-3,5-dicarbonitriles in the presence of ammonia

4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the ortho- ketonitrile fragment while preserving the halogen atom. The pyrrole ring annulation process proceeded regioselectively with the formation of a si...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-02, Vol.55 (2), p.167-171
Hauptverfasser: Grigor’ev, Arthur A., Kayukov, Yakov S., Nikiforova, Anastasiya L., Karpov, Sergey V., Shchegravina, Ekaterina S., Kayukova, Olga V., Tafeenko, Victor A.
Format: Artikel
Sprache:eng
Schlagworte:
Ammonia
Chemical reactions
Chemistry
Chemistry and Materials Science
Dioxane
Organic Chemistry
Pharmacy
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Zusammenfassung:4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the ortho- ketonitrile fragment while preserving the halogen atom. The pyrrole ring annulation process proceeded regioselectively with the formation of a single positional isomer.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02434-4