Diaminodiacid-based synthesis of macrocyclic peptides using 1,2,3-triazole bridges as disulfide bond mimetics

Diaminodiacid-based synthesis of macrocyclic peptides using 1,2,3-triazole bridges as disulfide bond mimetics

A new approach for the efficient construction of 1,2,3-triazole bridges as disulfide surrogates in peptides, utilizing the diaminodiacid strategy was established. Two thanatin derivatives were prepared with 1,5- and 1,4-disubstituted 1,2,3-triazole diaminodiacids as building blocks. The antibacteria...

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Veröffentlicht in:RSC advances 2017, Vol.7 (4), p.2110-2114
Hauptverfasser: Guo, Ye, Liu, Chao, Song, Hui, Wang, Feng-Liang, Zou, Yan, Wu, Qiu-Ye, Hu, Hong-Gang
Format: Artikel
Sprache:eng
Schlagworte:
Bridge construction
Peptides
Triazoles
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Zusammenfassung:A new approach for the efficient construction of 1,2,3-triazole bridges as disulfide surrogates in peptides, utilizing the diaminodiacid strategy was established. Two thanatin derivatives were prepared with 1,5- and 1,4-disubstituted 1,2,3-triazole diaminodiacids as building blocks. The antibacterial activity studies are also described here.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA26617G