Ehlers-Danlos Syndrome: It’s Not Your Normal Hoofbeats

The purpose of this article is to acquaint the reader with the presentation, diagnosis, and management of Ehlers-Danlos syndrome (EDS), a group of genetic connective tissue disorders. Progressive weakness of connective tissue is the underlying cause of all types of EDS. The symptoms of EDS are numerous, with variability in presentation. However, decreased quality of life caused by chronic pain and fatigue is a commonality of all types of EDS. This article will assist the nurse practitioner in recognizing EDS and offer guidance for treatment. •Ehlers-Danlos Syndrome (EDS) signs and symptoms derive from a defect in collagen.•Multisystem: collagen in tendons, ligaments, skin, heart valves, bone, cartilage, and muscle.•All types of EDS can have fatal arterial dissections at all ages.•Pregnancy can be life-threatening to mother and fetus.