Hyperlactacidemia Potentially Due to Linezolid Overexposure in a Liver Transplant Recipient

In accordance with our institution's antibiotic policy, which is oriented at optimizing therapy for critically ill patients [ 1 ], multiple blood samples were obtained to assess linezolid exposure during a dosing interval and were subsequently analyzed by high-performance liquid chromatography 2j. Pharmacokinetic analysis revealed significant plasma overexposure to linezolid ( 12-h area under the curve, 412.55 mg X h/L; maximum concentration, 43.32 mg/L; minimum concentration, 26.99 mg/ L) because of impaired clearance (1.51 L/ h) with a prolonged elimination half-life (16.57 h) [3].