Modifiye Poli(inülin) Mikro/Nanojellerinin İlaç Salımında Kullanımı ve Kan Uyumluluklarının Tespiti

Objective: For the use of these obtained micro/nanoparticles in living bodies, physical and chemical properties should be well-known and cells should not cause allergic, toxic or carcinogenic reactions. As a result, after characterization of the prepared p(inulin) particles, their use as drugcarrying system for biomedical applications and blood compatibilities were researched. Material and Methods: Poly(inulin) micro/nanogels were synthesized via reverse micelle microemulsion technique. The prepared p(inulin) particles are determined in spherical morphology with variance dimensions ranging from hundreds of nanometers to tens of micrometers with polydisperse size distribution. The sizes of p(inulin) particles are assessed by optic microscope and scanning electron microscope (SEM). Results:The prepared p(inulin) micro/nanogels are modified with a cationic molecule, 2-bromoethylamine (BEA) and their potential for drug carrier/delivery applications are investigated. It is demonstrated that the p(inulin) micro/nanogels with chemical modification can release Rosmarinic Acid (RA), chosen as a model drug, up to12 h in linear release profile in phosphate saline buffer (PBS) at pH 7.4 and at 37°C. Conclusion: p(inulin) micro/nanogels are shown to be more blood compatible from hemolysis and blood clotting tests, but the modified p(inulin) micro/nanogels are found to have toxic effects depending on the concentration.