Synthesis, Antioxidant, and Antileishmanial Activities of New Bis-N-amino Triazole Derivatives

Synthesis of new bis- N -imino triazole derivatives containing oxadiazole 2 , its Mannich base 3 , and the S-alkyl group 4 is presented. Bis- N -iminotriazole 2 is formed in the reaction of compound 1 with terephthalaldehyde. Bis N -iminotriazole derivatives containing Mannich base 3 are synthesized by the reaction of morpholine or piperidine with the compound 2 . The compound 2 also reacts with alkyl halides (butyl, pentyl, hexyl, heptyl) to give S-alkylated bis- N -imino triazoles 4 . Structures of the new compounds are characterized by IR, 1 H, and 13 C NMR, and mass spectral data. Antioxidant (FRAP and DPPH assay) and antileishmanial activities tests of the compounds indicate that the products 2, 3a , and 3b demonstrate moderate antioxidant activity in both DPPH and FRAP assays. The antileishmanial tests indicate high activity of the compounds 3a and 3b .