Lymphocyte subsets and assessment of cancer risk in renal transplant recipients

Lymphocyte subsets and assessment of cancer risk in renal transplant recipients

Renal transplant recipients have a well-recognized increased risk of de novo neoplasia. In this study, we investigated whether lymphocyte subset count could predict the risk of developing noncutaneous neoplasia (NCSC) in renal transplant recipients (RTR). Between January 1995 and December 1995, lymp...

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Veröffentlicht in:Transplant international 2002-09, Vol.15 (8), p.393
Hauptverfasser: Ducloux, Didier, Pierre-Louis Carron, Motte, Gerard, Abdelfatah Ab, Jean-Michel Rebibou, Bresson-Vautrin, Catherine, Tiberghien, Pierre, Saint-Hillier, Yves, Chalopin, Jean-Marc
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Sprache:eng
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Zusammenfassung:Renal transplant recipients have a well-recognized increased risk of de novo neoplasia. In this study, we investigated whether lymphocyte subset count could predict the risk of developing noncutaneous neoplasia (NCSC) in renal transplant recipients (RTR). Between January 1995 and December 1995, lymphocyte subsets (CD4, CD8, CD19) were measured in 281 RTR. This population was studied until November 1999 for the development of NCSC. The mean follow-up was 42±9 months. Neoplasm was diagnosed in 22 patients (7.9%). Patients who developed a cancer were significantly older (53.8±6 years vs 38±16 years, P
ISSN:0934-0874
1432-2277
DOI:10.1007/s00147-002-0410-4