Analytical spectrophotometric study for determining hydrocholrothiazide individually or with combination with triametrene in some pharmaceutical formulations

Other uses include diabetes insipidus, renal tubular acidosis, and to decrease the risk of kidney stones in those with high calcium level in the urine, and to decrease high blood pressure. [...]their simultaneous determination is hard when conventional spectrophotometric techniques are used. Normally, the method used to resolve a complex mixture of these drugs is mainly1, so we used the spectral derivation method to determine the two compounds. [...]various methods have been proposed to determine the amount of (HYD) individually and the two compounds in some pharmaceutical formulations, such as thin-layer chromatography (TLC)2, reverse phase high performance liquid chromatographic method3,4 (RP-HPLC) and amperometric detection5. According to USP legislation, the tablets must contain not less than 90.00 percent and not more than 110.00 percent of labeled amount.