Anti-Diabetic potential of a polyherbal formulation-A review

[...]natural extracts and its constituents derived from medicinal plants with hypoglycaemic properties and high efficacy but few side effects are urgently required as alternative approach for the prevention and treatment of diabetes. [...]in the present review, attempts have been made to establish the scientific validity for the antihyperglycemic property of Yesaka that has been claimed to be a unique formulation that helps in holistic management of blood glucose and diabetes-related complications. The other unclear fact is the mechanism of action of many herbs which has not been elucidated till date; therefore, the exact mechanisms of drug-herb interaction are also unclear. [...]date, various pharmacokinetic drug-herb interactions such as absorption, distribution, metabolism and pharmacodynamic interactions have been determined e.g. inhibition of lithium absorption by psyllium (an herb rich in mucilage), displacement of highly protein-bound drugs such as warfarin and carbamazepine by the pain-reducing salicylates present in meadowsweet and black willow, thus increasing the adverse effects of these drugs19. Oral administration of M. charantia fruits extract partially fix the altered metabolism of diabetic rats as seen for some metabolites profile of glucose, succinate, lactate, creatine, creatinine, urea and phenylacetylglycine to normal level. [...]M. charantia extract demonstrated to be potential anti-type 1 diabetic agent42.