Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgen-independent human prostate cancer cells PC3 and DU145

Because of unsatisfactory treatment options for prostate cancer (CaP) there is a need to develop novel preventive approaches for this malignancy. One such strategy is through chemoprevention by the use of non-toxic dietary substances and botanical products. We have shown previously that panduratin A...

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Veröffentlicht in:	Carcinogenesis (New York) 2006-07, Vol.27 (7), p.1454-1464
Hauptverfasser:	Yun, Jung-Mi, Kweon, Mee-Hyang, Kwon, Hoonjeong, Hwang, Jae-Kwan, Mukhtar, Hasan
Format:	Artikel
Sprache:	eng
Schlagworte:	5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide Adenocarcinoma - pathology androgen-independent human prostate carcinoma cells Androgens - metabolism Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins - drug effects Apoptosis Regulatory Proteins - metabolism bcl-2-Associated X Protein - drug effects bcl-2-Associated X Protein - metabolism bcl-Associated Death Protein - drug effects bcl-Associated Death Protein - metabolism Biological and medical sciences Blotting, Western CaP Carcinogenesis, carcinogens and anticarcinogens Caspases - drug effects Caspases - metabolism cdc2 cdk cdk inhibitor cdkI Cell Cycle - drug effects cell division cycle 2 kinase Cell Line, Tumor Chalcones - pharmacology cyclin dependent kinase Cyclin-Dependent Kinase Inhibitor p21 - drug effects Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-Dependent Kinase Inhibitor p27 - drug effects Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclin-Dependent Kinases - drug effects Cyclin-Dependent Kinases - metabolism Cyclins - drug effects Cyclins - metabolism Dose-Response Relationship, Drug FADD fas-associated death domain Flow Cytometry Gynecology. Andrology. Obstetrics Humans Inhibitory Concentration 50 Male Male genital diseases Medical sciences Membrane Glycoproteins - drug effects Membrane Glycoproteins - metabolism MTT Nephrology. Urinary tract diseases normal human prostate epithelial cell line PARP PC3 and DU145 Phytotherapy Plant Extracts - pharmacology poly (ADP-ribose) polymerase PrEC propidium iodide prostate cancer Prostatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction TNF TNF-Related Apoptosis-Inducing Ligand TRAIL tumor necrosis factor Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism Tumors Tumors of the urinary system Urinary tract. Prostate gland Zingiberaceae - chemistry
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