Study of regioselectivity in cyanomethylation of 4-(trifluoromethyl)pyrimidin-2(1Н)-ones
Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1 Н )-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solventfree conditions.
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| Veröffentlicht in: | Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-01, Vol.55 (1), p.66-71 |
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| container_end_page | 71 |
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| container_issue | 1 |
| container_start_page | 66 |
| container_title | Chemistry of heterocyclic compounds (New York, N.Y. 1965) |
| container_volume | 55 |
| creator | Tkachuk, Viktor M. Melnykov, Serhii V. Vorobei, Anastasiia V. Sukach, Volodymyr A. Vovk, Mykhailo V. |
| description | Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1
Н
)-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solventfree conditions. |
| doi_str_mv | 10.1007/s10593-019-02420-w |
| format | Article |
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| issn | 0009-3122 1573-8353 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Chemistry Chemistry and Materials Science Decarboxylation Organic Chemistry Pharmacy Reaction products Reagents Regioselectivity |
| title | Study of regioselectivity in cyanomethylation of 4-(trifluoromethyl)pyrimidin-2(1Н)-ones |
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