Study of regioselectivity in cyanomethylation of 4-(trifluoromethyl)pyrimidin-2(1Н)-ones

Study of regioselectivity in cyanomethylation of 4-(trifluoromethyl)pyrimidin-2(1Н)-ones

Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1 Н )-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solventfree conditions.

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Bibliographische Detailangaben
Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-01, Vol.55 (1), p.66-71
Hauptverfasser: Tkachuk, Viktor M., Melnykov, Serhii V., Vorobei, Anastasiia V., Sukach, Volodymyr A., Vovk, Mykhailo V.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Decarboxylation
Organic Chemistry
Pharmacy
Reaction products
Reagents
Regioselectivity
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Beschreibung
Zusammenfassung:Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1 Н )-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solventfree conditions.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02420-w