Computational Evaluation of the Promoter Region of the Brain Derived Neurotrophic Factor (BDNF) Gene; towards its Involvement in Stress-Induced Haematological Parameters Alteration in Medical Students

[...]the sequences of BDNF gene and promoter region we can take it from many genetics website such as Genbank, but there's no mapping for this sequences; mapping means where and which elements in the sequences that is not mentions until now. Furthermore, the excessive levels of ROS can lead to damage cellular proteins including cytoskeletal proteins and finally disrupt GI tract barrier to increase gut permeability which causes malabsorption of nutrient factors necessary to erythropoiesis and later decrease RBC's count with abnormal RBC's indices31,32. [...]stress can be another cause of anaemia33, 34, but only few studies have been shown this relationship and still need more study and investigation. The investigations have been shown that undergraduate medical students suffer a high level of stress more than other populations36-39. [...]undergraduate medical students have highest chance to all complications of high stress levels, including abnormal haematological parameters; until now this issue still need more study. [...]date, no proper study has been evidenced to assess levels of stress and its correlation with the haematological parameters and BDNF gene in medical students.