Scaffolds for Biomolecule Delivery and Controlled Release-A Review

[...]Scaffolds which are highly porous structures, allows tissue growth and possesses the potential for the targeted delivery of cells as well as other molecules such as DNA, drugs etc. into the respective tissues. [...]if we use the same methodology in tissue engineering over here where we deliver localized growth factors and scaffolds to the target areas, then the regeneration of the tissue is again possible and this could serve as the benchmark for future medical treatments. The results showed high and sustained elution rate with antimicrobial effect intact [34,35,36]. [...]biodegradable scaffolds were synthesized for efficient and sustained drug delivery in the treatment of osteomyelitis: for instance, * Proteins such as collagens from skin or tendons of animals help in mineralization and regeneration of bone. Any defect in this signaling process leads to a condition called craniosynostosis, characterized by visible craniofacial disfigurations with severe neurological problems. Since there is a need for sustained long-term expression of cytokines for craniofacial development, PLGA and polycaprolactone (PCL) scaffolds were widely used.