Evidence based Evaluation of Antidiabetic Potential of Yesaka on Streptozotocin Diabetic Rats

The antioxidant activity of Yesaka was also evaluated by DPPH. Fortunately, the currently available treatments such as hormone therapy (insulin), oral administration of glucose-lowering agents such as alpha-glucosidase inhibitors, sulfonylureas, biguanides and thiazolidinediones6,7 lowers the blood sugar levels, but each exhibits its own potential adverse effects. [...]none can effectively control the delayed diabetic complications such as nephropathy, neuropathy, retinopathy and cardiovascular diseases. [...]natural extracts and its constituents derived from medicinal plants with high efficacy but few side effects are urgently required as alternative approach for the prevention and treatment of diabetes compared to their synthetic counterparts. [...]polyherbal formulation is safe, cost effective, easily available and when taken with the standard marketed preparation like Glipizide showed no adverse effect.