Synthesis and Antioxidant Activity of Some New Coumarin Incorporated 4-Thiazolidinone Derivatives

All the newly synthesized compounds were evaluated for in-vitro antioxidant activities like DPPH, nitric oxide and hydrogen peroxide radical scavenging assay models. [...]an attempt was made towards the incorporation of 4-thiazolidinone with coumarin moiety and to probe how this combination could influence the biological activity. Nitric oxide inhibition method:14 Nitric oxide generated from sodium nitroprusside in aqueous solution at physiological pH interacts with oxygen to produce nitrite ions, which were measured by the method of garret. The percentage scavenging of hydrogen peroxide of compounds and standard were calculated using formula % scavenging = {(A0-A1)/Aø}·100 A0 - absorbance of control A1 - Absorbance of sample 3.DPPH (1, 1-diphenyl-2-picrryl-hydrazyl) free radical scavenging assay:16 Antioxidant activity is a prerequisite for performing many related biological activities, including anticancer, antiallergic, anti inflammatory, antidiabetic etc.