Effects of Oxidative Stress on Alzheimer's Disease, Haematological Perspective

[...]this review article is designed to unearth the effect of oxidative stress in AD patients and incite leading researchers to generate database that will help in understand the relationship between oxidative stress and haematological parameters especially in AD patients. [...]providing a link between the membrane and the cytoskeleton accountable for maintaining the cell shape, and providing for the reactions of cytosolic proteins with the membrane through the amino terminal region that emerges into the cytosol. The excessive levels of ROS can lead to damage cellular proteins including cytoskeletal proteins and ultimately disrupting GI tract barrier resulting an increase in gut permeability which contributes to inflammation in a variety of GI tract diseases84, 85. [...]oxidative stress resulting in AD patients can lead to GI disorders including malabsorption which leads to deficiency of important nutrients in the body including haematinic factors i.e., minerals and vitamins important to erythropoiesis. [...]only two studies have been shown this relationship and discussed it in general. [...]it can be suggested here the that more research investigations are needed to establish a more comprehensive evidences on the relationship of oxidative stress and anaemia (Table 1).