Pharmacogenetics and Genetic Polymorphism of CYP Enzymes in Indian Population: A Clinical Review

[...]the genetic variation at CYP1, CYP2C8, CYP3A4, CYP2C9, CYP2C19 and CYP2D6 was described at global as well as in India by genotyping new population samples and by collecting data from the literature. Altered activity variants occur in all geographic regions, reaching extremely high frequencies in some populations, which has many important clinical consequences; each of the CYP genes studied shows a distinct geographic pattern of variation reflecting past evolutionary processes; effect of demography on pharmacogenetic variation should be also considered at themicro geographic scale; and several geographic regions of pharmacogenetic interest are still poorly characterized. Li Y, Millikan RC, Bell DA, Cui L, TseCh-KJ, Newman B, Conway K. Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study. AquilantecL, Langaee TY, Lopez Lm, Yarandi HN, Tromberg JS, Mohuczy D, et al., Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2c9 gene polymorphisms on warfarin dose requirements.