Modulation by leptin of proliferation and apoptosis in vascular endothelial cells

Modulation by leptin of proliferation and apoptosis in vascular endothelial cells

AIM: Plasma leptin concentrations not only correlate with body fat mass, but also with the degree of hypertensive retinopathy. The present study was designed to further examine, whether leptin's proliferative, proangiogenic activity relates to a yet uncovered anti-apoptotic effect. RESULTS: Lep...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International Journal of Obesity 2002-04, Vol.26 (4), p.577-580
Hauptverfasser: Artwohl, M, Roden, M, Hölzenbein, T, Freudenthaler, A, Waldhäusl, W, Baumgartner-Parzer, S.M
Format: Artikel
Sprache:eng
Schlagworte:
adults
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Body fat
Cell cycle
Cell Division - drug effects
Cells, Cultured
Endocrinology
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Female
Gene Expression - drug effects
genes
Genes, p53
human umbilical vein endothelial cells
Humans
Hypertension
Kinases
leptin
Leptin - pharmacology
Medical sciences
Metabolic diseases
Metabolism
Microcirculation
Obesity
Ophthalmology
Protein expression
Proteins
Proto-Oncogene Proteins c-bcl-2 - genetics
retinal diseases
Retinoblastoma
Retinopathies
RNA, Messenger - analysis
Skin - blood supply
Umbilical Veins
Uterus - blood supply
Veins
Veins & arteries
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:AIM: Plasma leptin concentrations not only correlate with body fat mass, but also with the degree of hypertensive retinopathy. The present study was designed to further examine, whether leptin's proliferative, proangiogenic activity relates to a yet uncovered anti-apoptotic effect. RESULTS: Leptin (10-50 nmol/l) concentration-dependently reduced apoptosis in HUVECs (human umbilical vein endothelial cells), HAVECs (human adult vein endothelial cells) and HMECs (human microvascular endothelial cells) by 20% (P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801947