No evidence of an additive inhibitory feeding effect following PP and PYY3-36 administration

Pancreatic polypeptide (PP) and peptide YY (PYY) are released by the gut in response to nutrients and inhibit food intake in rodents and humans. We hypothesized that PP and PYY3-36 would inhibit feeding additively. Fasted male C57BL/6 mice were injected intraperitoneally with saline, PP, PYY3-36 or...

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Veröffentlicht in:	International Journal of Obesity 2008-09, Vol.32 (9), p.1438-1440
Hauptverfasser:	Neary, N.M, McGowan, B.M, Monteiro, M.P, Jesudason, D.R, Ghatei, M.A, Bloom, S.R
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Biological and medical sciences Drug dosages Energy energy intake Epidemiology fasting Feeding feeding level Food food intake Health Promotion and Disease Prevention hormonal regulation Hormones Internal Medicine Medical sciences Medicine Medicine & Public Health Metabolic Diseases mice Nutrients nutrition physiology Obesity pancreatic polypeptide peptide YY Polypeptides Public Health Rodents short-communication Variance analysis
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Beschreibung
Zusammenfassung:	Pancreatic polypeptide (PP) and peptide YY (PYY) are released by the gut in response to nutrients and inhibit food intake in rodents and humans. We hypothesized that PP and PYY3-36 would inhibit feeding additively. Fasted male C57BL/6 mice were injected intraperitoneally with saline, PP, PYY3-36 or PP+PYY3-36 (n=7-10). Food intake at 1 h was significantly inhibited by 6 nmol kg-1 PP and by 6 nmol kg-1 PYY3-36 (P
ISSN:	0307-0565 1476-5497
DOI:	10.1038/ijo.2008.95