Relationship between peroxisome proliferator-activated receptor gamma and retinoic acid receptor alpha gene expression in obese human adipose tissue

Relationship between peroxisome proliferator-activated receptor gamma and retinoic acid receptor alpha gene expression in obese human adipose tissue

Objective: To investigate in human adipose tissue a possible relationship between per oxisome proliferator-activated receptor gamma (PPAR) and retinoic acid receptor alpha (RAR) gene expression, two genes involved in the control of adipocyte differentiation. Subjects: Ten lean control women (age 31-...

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Veröffentlicht in:International Journal of Obesity 2002-07, Vol.26 (7), p.920-927
Hauptverfasser: Redonnet, A, Bonilla, S, Noël-Suberville, C, Pallet, V, Dabadie, H, Gin, H, Higueret, P
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Adipocytes
Adipose tissue
Adipose Tissue - metabolism
Adult
Biological and medical sciences
Body fat
Body Mass Index
Energy Intake
Female
Fundamental and applied biological sciences. Psychology
Gene amplification
Gene Expression
genes
Humans
Medical sciences
messenger RNA
Metabolic diseases
Metabolism
Nutrition research
Obesity
Obesity - metabolism
quantitative polymerase chain reaction
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Retinoic Acid - genetics
retinoic acid
Retinoic Acid Receptor alpha
RNA, Messenger - analysis
Transcription Factors - genetics
Triglycerides - blood
Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
Weight control
Weight Gain
Weight Loss
women
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Zusammenfassung:Objective: To investigate in human adipose tissue a possible relationship between per oxisome proliferator-activated receptor gamma (PPAR) and retinoic acid receptor alpha (RAR) gene expression, two genes involved in the control of adipocyte differentiation. Subjects: Ten lean control women (age 31-60 y, body mass index (BMI) 18-24.7 kg/m2) and an obese group of 15 women (age 27-62 y, BMI 30-57.5 kg/m2), of whom 10 subjects were in weight-gain phase and five were in weight-loss phase. Measurements: We assessed the relative PPAR and RAR mRNA levels in subcutaneous abdominal adipose tissue using a real-time PCR method. Results: PPAR mRNA level were significantly increased (+91%; P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0802025