11 Novice marathon training reverses vascular ageing

BackgroundAgeing is strongly associated with aortic stiffening, contributing to increased cardiovascular risk even in healthy individuals. Aortic stiffness is reduced in lifelong athletes, but whether training in novice runners can modify this process remains unclear. We hypothesized that exercise training for a first-time marathon would have beneficial effects on the age-related increase in aortic stiffness.MethodsUntrained healthy volunteers were recruited prior to starting training for the London Marathon. Assessment pre-training and two weeks post-marathon included central (aortic) BP (cBP), and phase contrast 1.5T CMR in the ascending (Ao-A) and descending thoracic aorta at two levels (pulmonary artery bifurcation and diaphragm – Ao-P and Ao-D). Aortic distensibility and beta-stiffness (β, a pressure-independent measure) were measured and correlated with chronological age at baseline to derive biological aortic age before and after training. Data are mean changes (95% confidence intervals).Results139 first-time marathon completers (age range 21–69, 50% male) had assessment pre-training and 2 weeks post-marathon completion. As expected, increasing age decade was associated with decreasing distensibility by 2.3, 1.9 and 3.1 × 10-3mmHg-1 for the Ao-A, Ao-P, and Ao-D respectively (partial r=0.4–0.5), figure 1.Abstract 11 Figure 1Age and distal descending aortic distensibility before training (left), and the change with training (right)Training decreased cSBP and cDBP by 4 (2.5–5.3) and 3 mmHg(1.6–3.6), Table 1. With training, descending aortic distensibility increased at both Ao-P and Ao-D levels (by 9%,p=0.009% and 17%,p=0.001), whilst unchanged in the ascending aorta. This translated to a reduction in biological aortic age at Ao-P by 3.9 (1.1–7.5) and Ao-D 4.5 years(1.8–8.2). β decreased by 7% at the Ao-D level,p=0.02. Participants with slower marathon running times (Ao-P partial r:−0.20,p