Formulation and evaluation of Self-Poring osmotic tablet of diltiazem HCl for the treatment of hypertension

From result of invitro drug release study it was clear that more concentration of pore former and osmogens releases drug in short time while less concentration takes more time for drug release. [...]it is necessary to use SLS, polymer and osmogens in balance concentration for getting optimum control release at zero order upto 24 hrs. [...]the tablet core were coated using ethy cellulose as semipermeable membrane, SLS as pore former, PEG as plasticizer and acetone as solvent. A decrease in release kinetic was observed on decreasing pore forming agents and osmogens. Because the osmotic pressure created by osmogens will be less if we are using less amount of osmogens since release of drug depends on the expulsion of drug by osmogens also more the size of pore more will be the drug release. Through the invitrorelease study it can be concluded that the prepared self-poring osmotic tablet releases drug in optimum level upto 24 hrs also contolled and zero order release was obtained. [...]we can say that self-poring tablets emerged as a new method and delivery system for getting simplest of providing treatment of that drug which are needed for long term therapy also eliminating fluctuations in plasma concentration^ toxicity and less dosing while treatment.