Formulation and Evaluation of Risperidone Loaded Mouth-Dissolving Film

[...]oral administration of Risperidone has drawbacks such as hepatic first pass metabolism which is overcome by means of mouth dissolving film.In the present research, mouthdissolving films of riseperidone were developed using low viscosity grades of HPMC K15 and sorbitol polymers and propylene glycol as plasticizer and purified water as solvent followed by solvent casting method. [1-3] Fast dissolving films a type of oral drug delivery system for the oral delivery of the drug, was developed based on the technology of the transdermal patch. Aqueous solution 'A' was prepared by dissolving HPMCk15 polymer in 15 ml cool water with stirring to produce solution and kept for 24 hrs. to remove all the air bubbles and form clear solution Aqueous solution 'B' was prepared by dissolving Risperidone, sorbital, citric acid and propylene glycol in specific proportion in 5 ml of distilled water. [...]a semi-synthetic cellulose derivative which is affordable and abundantly available can be used as a potential drug release modifier and also used to improve flexibility and processability in the mouth dissolving films.