Antimicrobial Susceptibility and Resistance Profile of Pseudomonas aeruginosa Isolates from Patients at an Egyptian Hospital

Pseudomonas aeruginosa is a standout amongst the most hazardous microorganisms of high morbidity and mortality rates especially in debilitated patients with few successful antibiotic choices available due to the rapid dissemination of antimicrobials resistance. [...]the present study was intended to examine the susceptibility and resistance pattern of various Pseudomonas aeruginosa clinical isolates taken from patients at an Egyptian hospital against commonly prescribed anti-pseudomonal antibiotics. Infections caused by resistant isolates are an issue of great concern as they are accompanied by 3-fold higher mortality rates and 9-fold higher rate of secondary bacteremia12. Since the antibiotic susceptibility profile of Pseudomonas aeruginosa is in continuous change, this study, like many other studies on susceptibility profile, aimed at determining the most proper empirical antimicrobial therapy that can be helpful in the efficacious management of pseudomonal infections. According to the type of specimens, it was found that the 44 Pseudomonas aeruginosa isolates from urine specimens showed the highest susceptibility against colistin sulfate 39/44 (88.64%), followed by imipenem with susceptibility equal to 33/44 (75%), while the highest resistance of urine isolates was against piperacillin 10/ 44 (22.73%), Table 2. [...]although the high speed of resistance evolving among Pseudomonas aeruginosa and the presence of considerable percentage of MDR strains, Pseudomonas aeruginosa isolates in this study were susceptible to colistin sulfate and with lower degree to the quinolones (ciprofloxacin and levofloxacin) which is a good information for the prescribers in Egypt to give careful consideration in their future rational prescriptions and use of these antibiotics should be the main focus.