A highly specific and ultrasensitive p-aminophenylether-based fluorescent probe for imaging native HOCl in live cells and zebrafish

It is very important to detect native hypochlorous acid (HOCl) in the complex biosystems owing to the important roles of HOCl in the immune defense and the pathogenesis of numerous diseases. In this paper, a new p-aminophenylether-based fluorescent probe PAPE-HA was developed for specific detection...

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Veröffentlicht in:	Analytica chimica acta 2019-04, Vol.1052, p.131-136
Hauptverfasser:	Jia, Pan, Zhuang, Zihan, Liu, Caiyun, Wang, Zuokai, Duan, Qingxia, Li, Zilu, Zhu, Hanchuang, Du, Bin, Zhu, Baocun, Sheng, Wenlong, Kang, Baotao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioimaging Cell Survival Danio rerio Fluorescent Dyes - metabolism Fluorescent indicators Fluorescent probe Hydroxynaphthalimide Hypochlorous acid Hypochlorous acid (HOCl) Hypochlorous Acid - metabolism Immune system Limit of Detection Mice Optical Imaging P-aminophenylether Pathogenesis Phenyl Ethers - metabolism RAW 264.7 Cells Zebrafish
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Beschreibung
Zusammenfassung:	It is very important to detect native hypochlorous acid (HOCl) in the complex biosystems owing to the important roles of HOCl in the immune defense and the pathogenesis of numerous diseases. In this paper, a new p-aminophenylether-based fluorescent probe PAPE-HA was developed for specific detection of HOCl. Probe PAPE-HA could implement the quantitative detection of HOCl ranging from 0 to 1 μM and the detection limit was obtained as low as 1.37 nM. Additionally, probe PAPE-HA could reach a rapid response for HOCl (
ISSN:	0003-2670 1873-4324
DOI:	10.1016/j.aca.2018.11.031