Palladium Catalyzed Controllable Mono‐ or Di‐Allylic Substitution Reaction of Benzothiazolylacetate with Allylic Alcohols

Palladium Catalyzed Controllable Mono‐ or Di‐Allylic Substitution Reaction of Benzothiazolylacetate with Allylic Alcohols

A Pd(PPh3)4/acid catalyzed highly efficient and mono‐ or di‐selective allylic substitution reaction of benzothiazolylacetate and allylic alcohols has been developed. The mono‐ and di‐selectivities could be efficiently controlled by changing the reaction solvent and temperature, affording various mon...

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Veröffentlicht in:Advanced synthesis & catalysis 2019-03, Vol.361 (6), p.1322-1334
Hauptverfasser: Yan, Peipei, Pan, Shulei, Hu, Jinjin, Lu, Limei, Zeng, Xiaofei, Zhong, Guofu
Format: Artikel
Sprache:eng
Schlagworte:
Activated methylene
Alcohol
Alcohols
Allylic alcohol
Allylic substitution
Mono- or di-selective
Palladium
Palladium catalysis
Stability
Substitution reactions
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Zusammenfassung:A Pd(PPh3)4/acid catalyzed highly efficient and mono‐ or di‐selective allylic substitution reaction of benzothiazolylacetate and allylic alcohols has been developed. The mono‐ and di‐selectivities could be efficiently controlled by changing the reaction solvent and temperature, affording various mono‐ and di‐allylated products in good to excellent yields and selectivities. Both linear and branched allylic alcohols as well as allyl alcohol could all be well tolerated in the reaction.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201801351