Development of biocompatible 1D CuO nanoneedles and their potential for sensitive, mass-based detection of anti-tuberculosis drugs
Unique physical and chemical properties make 1D nanomaterials very attractive and their window of applications is broadened by the addition of biocompatible materials. Similarly, the massive side effects associated with the frequent use of antibiotics make it crucial to analyze the quantity and dete...
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| Veröffentlicht in: | Applied nanoscience 2019-09, Vol.9 (6), p.1341-1351 |
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| creator | Bano, Khizra Bajwa, Sadia Z. Bassous, Nicole J. Webster, Thomas J. Shaheen, Ayesha Taj, Ayesha Hameed, Sadaf Tehseen, Bushra Dai, Zhifei Iqbal, M. Zubair Khan, Waheed S. |
| description | Unique physical and chemical properties make 1D nanomaterials very attractive and their window of applications is broadened by the addition of biocompatible materials. Similarly, the massive side effects associated with the frequent use of antibiotics make it crucial to analyze the quantity and detect even the subservient amounts of antibiotics in vivo following their administration to patients. The present study describes the one-pot solvothermal approach to produce 1D CuO nanoneedles. Microscopic investigations revealed the presence of nanoneedles of about 8–15 nm in size with negative surface charge (− 30.51 mV). These structures were explored for the targeted detection of the anti-tubercular agent rifampicin. This developed interface showed excellent sensitivity, with the limit of detection as low as 9.4 nM and the limit of quantification as 20 nM. This sensor exhibited good selectivity towards the structural analogs (rifabutene, rifapentine) of the analyte. This study represents the potential of 1D nanomaterial in biomedical applications such as the development of interfaces for online monitoring. |
| doi_str_mv | 10.1007/s13204-019-01003-7 |
| format | Article |
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Zubair ; Khan, Waheed S.</creator><creatorcontrib>Bano, Khizra ; Bajwa, Sadia Z. ; Bassous, Nicole J. ; Webster, Thomas J. ; Shaheen, Ayesha ; Taj, Ayesha ; Hameed, Sadaf ; Tehseen, Bushra ; Dai, Zhifei ; Iqbal, M. Zubair ; Khan, Waheed S.</creatorcontrib><description>Unique physical and chemical properties make 1D nanomaterials very attractive and their window of applications is broadened by the addition of biocompatible materials. Similarly, the massive side effects associated with the frequent use of antibiotics make it crucial to analyze the quantity and detect even the subservient amounts of antibiotics in vivo following their administration to patients. The present study describes the one-pot solvothermal approach to produce 1D CuO nanoneedles. Microscopic investigations revealed the presence of nanoneedles of about 8–15 nm in size with negative surface charge (− 30.51 mV). These structures were explored for the targeted detection of the anti-tubercular agent rifampicin. This developed interface showed excellent sensitivity, with the limit of detection as low as 9.4 nM and the limit of quantification as 20 nM. This sensor exhibited good selectivity towards the structural analogs (rifabutene, rifapentine) of the analyte. This study represents the potential of 1D nanomaterial in biomedical applications such as the development of interfaces for online monitoring.</description><identifier>ISSN: 2190-5509</identifier><identifier>EISSN: 2190-5517</identifier><identifier>DOI: 10.1007/s13204-019-01003-7</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antibiotics ; Biocompatibility ; Biomedical materials ; Chemical properties ; Chemistry and Materials Science ; In vivo methods and tests ; Materials Science ; Membrane Biology ; Nanochemistry ; Nanomaterials ; Nanotechnology ; Nanotechnology and Microengineering ; Organic chemistry ; Original Article ; Selectivity ; Side effects ; Surface charge ; Tuberculosis</subject><ispartof>Applied nanoscience, 2019-09, Vol.9 (6), p.1341-1351</ispartof><rights>King Abdulaziz City for Science and Technology 2019</rights><rights>Applied Nanoscience is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-8bcc7cc22518be4aeba2509513debc369c674a854b721217aebd9e6c77e8f55d3</citedby><cites>FETCH-LOGICAL-c319t-8bcc7cc22518be4aeba2509513debc369c674a854b721217aebd9e6c77e8f55d3</cites><orcidid>0000-0002-4755-0267</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13204-019-01003-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13204-019-01003-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Bano, Khizra</creatorcontrib><creatorcontrib>Bajwa, Sadia Z.</creatorcontrib><creatorcontrib>Bassous, Nicole J.</creatorcontrib><creatorcontrib>Webster, Thomas J.</creatorcontrib><creatorcontrib>Shaheen, Ayesha</creatorcontrib><creatorcontrib>Taj, Ayesha</creatorcontrib><creatorcontrib>Hameed, Sadaf</creatorcontrib><creatorcontrib>Tehseen, Bushra</creatorcontrib><creatorcontrib>Dai, Zhifei</creatorcontrib><creatorcontrib>Iqbal, M. Zubair</creatorcontrib><creatorcontrib>Khan, Waheed S.</creatorcontrib><title>Development of biocompatible 1D CuO nanoneedles and their potential for sensitive, mass-based detection of anti-tuberculosis drugs</title><title>Applied nanoscience</title><addtitle>Appl Nanosci</addtitle><description>Unique physical and chemical properties make 1D nanomaterials very attractive and their window of applications is broadened by the addition of biocompatible materials. Similarly, the massive side effects associated with the frequent use of antibiotics make it crucial to analyze the quantity and detect even the subservient amounts of antibiotics in vivo following their administration to patients. The present study describes the one-pot solvothermal approach to produce 1D CuO nanoneedles. Microscopic investigations revealed the presence of nanoneedles of about 8–15 nm in size with negative surface charge (− 30.51 mV). These structures were explored for the targeted detection of the anti-tubercular agent rifampicin. This developed interface showed excellent sensitivity, with the limit of detection as low as 9.4 nM and the limit of quantification as 20 nM. This sensor exhibited good selectivity towards the structural analogs (rifabutene, rifapentine) of the analyte. This study represents the potential of 1D nanomaterial in biomedical applications such as the development of interfaces for online monitoring.</description><subject>Antibiotics</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Chemical properties</subject><subject>Chemistry and Materials Science</subject><subject>In vivo methods and tests</subject><subject>Materials Science</subject><subject>Membrane Biology</subject><subject>Nanochemistry</subject><subject>Nanomaterials</subject><subject>Nanotechnology</subject><subject>Nanotechnology and Microengineering</subject><subject>Organic chemistry</subject><subject>Original Article</subject><subject>Selectivity</subject><subject>Side effects</subject><subject>Surface charge</subject><subject>Tuberculosis</subject><issn>2190-5509</issn><issn>2190-5517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAURYsoKKN_wFXArdV8NJPpUsZPENzoOiTp65ihk9S8dMCtv9zoiO4MPPIW596QU1WnjF4wStUlMsFpU1PWlqFU1GqvOuKspbWUTO3_7rQ9rE4Q17Qc2ai5kEfVxzVsYYjjBkImsSfWRxc3o8neDkDYNVlOTySYEANANwASEzqSX8EnMsZcQt4MpI-JIAT02W_hnGwMYm0NQkc6yOCyj-Gr2xS6zpOF5KYhokfSpWmFx9VBbwaEk597Vr3c3jwv7-vHp7uH5dVj7QRrc72wzinnOJdsYaExYA0vX5JMdGCdmLdurhqzkI1VnHGmCtC1MHdKwaKXshOz6mzXO6b4NgFmvY5TCuVJXQQxLiRrWKH4jnIpIibo9Zj8xqR3zaj-0q13unXRrb91a1VCYhfCAocVpL_qf1KfxHKEtw</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Bano, Khizra</creator><creator>Bajwa, Sadia Z.</creator><creator>Bassous, Nicole J.</creator><creator>Webster, Thomas J.</creator><creator>Shaheen, Ayesha</creator><creator>Taj, Ayesha</creator><creator>Hameed, Sadaf</creator><creator>Tehseen, Bushra</creator><creator>Dai, Zhifei</creator><creator>Iqbal, M. Zubair</creator><creator>Khan, Waheed S.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-4755-0267</orcidid></search><sort><creationdate>20190901</creationdate><title>Development of biocompatible 1D CuO nanoneedles and their potential for sensitive, mass-based detection of anti-tuberculosis drugs</title><author>Bano, Khizra ; Bajwa, Sadia Z. ; Bassous, Nicole J. ; Webster, Thomas J. ; Shaheen, Ayesha ; Taj, Ayesha ; Hameed, Sadaf ; Tehseen, Bushra ; Dai, Zhifei ; Iqbal, M. 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| subjects | Antibiotics Biocompatibility Biomedical materials Chemical properties Chemistry and Materials Science In vivo methods and tests Materials Science Membrane Biology Nanochemistry Nanomaterials Nanotechnology Nanotechnology and Microengineering Organic chemistry Original Article Selectivity Side effects Surface charge Tuberculosis |
| title | Development of biocompatible 1D CuO nanoneedles and their potential for sensitive, mass-based detection of anti-tuberculosis drugs |
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