Risks of Opioids in ST-Elevation Myocardial Infarction: A Review

Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This...

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Veröffentlicht in:	Drug safety 2018-12, Vol.41 (12), p.1303-1308
Hauptverfasser:	Tavenier, Anne Henrieke, Hermanides, Renicus Suffridus, Ottervanger, Jan Paul, Ter Horst, Peter Gerrit Johannes, Kedhi, Elvin, van ‘t Hof, Adriaan W. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics, Opioid - adverse effects Blood platelets Blood pressure Constipation Drug Safety and Pharmacovigilance Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - physiopathology Heart attacks Humans Implants Inhibition Medicine Medicine & Public Health Mortality Myocardial infarction Narcotics Opioids Pain Pharmacology/Toxicology Platelets Respiratory Insufficiency - chemically induced Respiratory Insufficiency - diagnosis Respiratory Insufficiency - physiopathology Review Article Risk Factors Side effects ST Elevation Myocardial Infarction - chemically induced ST Elevation Myocardial Infarction - diagnosis ST Elevation Myocardial Infarction - physiopathology Surgical implants Thromboembolism Thrombosis Vomiting
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Beschreibung
Zusammenfassung:	Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This may cause suboptimal platelet inhibition and increased risk of acute stent thrombosis. Some clinical studies have already demonstrated these negative results. Alternative strategies to optimize platelet inhibition and pain relief in STEMI are being investigated. Clinicians should become more aware of the potential side effects of opioids in STEMI.
ISSN:	0114-5916 1179-1942
DOI:	10.1007/s40264-018-0710-y